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Nathalia Mantovani Pena, PhD

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Nathalia graduated in Biomedical Science in 2009 focusing on Molecular Biology. During her undergrad she worked with resistance mutations and vaccine-escape mutations in Hepatitis B. During her Master’s degree she evaluated transmitted resistance mutations to Integrase inhibitors in HIV infection in the city of Sao Paulo, Brazil. Her Ph.D. focused on analyzing DNA methylation patterns associated with latency in HIV infection.


Research Interest: Infectious diseases, HIV-1, Epigenetics, DNA methylation, Host-pathogen interaction.


Fun Fact:

Hometown: Santos, SP, Brazil

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B.Sc., Biomedical Science – Centro Universitario Lusiada, Brazil(2009)

M.Sc., Science - Federal University of Sao Paulo, Brazil (2012)

Ph.D., Science – Federal University of Sao Paulo, Brazil (2016)

Publications

  1. Immunogenicity of personalized dendritic-cell therapy in HIV-1 infected individuals under suppressive antiretroviral treatment: interim analysis from a phase II clinical trial. AIDS Research and Therapy, v.19, p.1-, 2022. De Almeida Baptista, Marcella Vassão; Da Silva, Laís Teodoro; Samer, Sadia; Oshiro, Telma Miuki; Shytaj, Iart Luca; Giron, Leila B.; Pena, Nathalia Mantovani; Cruz, Nicolly; Gosuen, Gisele Cristina; Ferreira, Paulo Roberto Abrão; Cunha-Neto, Edécio; Galinskas, Juliana; Dias, Danilo; Sucupira, Maria Cecilia Araripe; De Almeida-Neto, Cesar; Salomão, Reinaldo; Da Silva Duarte, Alberto José; Janini, Luís Mário; Hunter, James R.; Savarino, Andrea; Juliano, Maria Aparecida; Diaz, Ricardo Sobhie. 

  2. 3D Bioprinted Neural-Like Tissue as a Platform to Study Neurotropism of Mouse-Adapted SARS-CoV-2. Advanced Biology. , v.22, p.2200002 , 2022. Melo, Bruna A. G.; Mundim, Mayara V.; Lemes, Robertha M. R.; Cruz, Elisa M.; Ribeiro, Tais N.; Santiago, Carolina F.; Fonsêca, Jéssica H. L.; Benincasa, Julia C.; Stilhano, Roberta S.; Mantovani, Nathalia; Santana, Luiz C.; Durães-Carvalho, Ricardo; Diaz, Ricardo S.; Janini, Luiz M. R.; Maricato, Juliana T.; Porcionatto, Marimelia A.

  3. Latency-associated DNA methylation patterns among HIV-1 infected individuals with distinct disease progression courses or antiretroviral virologic response. Scientific Reports. , v.11, p.22993 - , 2021. Mantovani, Nathalia; Defelicibus, Alexandre; Da Silva, Israel Tojal; Cicero, Maira Ferreira; Santana, Luiz Claudio; Arnold, Rafael; De Castro, Daniela Funayama; Duro, Rodrigo Lopes Sanz; Nishyama-Jr, Milton Yutaka; Junqueira-de-Azevedo, Inácio Loiola Meirelles; Da Silva, Bosco Christiano Maciel; Da Silva Duarte, Alberto José; Casseb, Jorge; De Barros Tenore, Simone; Hunter, James; Diaz, Ricardo Sobhie; Komninakis, Shirley Cavalcante Vasconcelos.

  4. Nitazoxanide superiority to placebo to treat moderate COVID-19 - A Pilot prove of concept randomized double-blind clinical trial. EClinicalMedicine. , v.37, p.100981 - , 2021. Blum, Vinicius Fontanesi; Cimerman, Sérgio; Hunter, James R; Tierno, Paulo; Lacerda, Acioly; Soeiro, Alexandre; Cardoso, Florentino; Bellei, Nancy Cristina; Maricato, Juliana; Mantovani, Nathalia; Vassao, Marcella; Dias, Danilo; Galinskas, Juliana; Janini, Luiz Mário Ramos; Santos-Oliveira, Joanna Reis; Da-Cruz, Alda Maria; Diaz, Ricardo Sobhie. 

  5. Identification of a new hepatitis B virus recombinant D2/D3 in the city of São Paulo, Brazil. Arch Virol. 2016 Oct 27. Santana LC, Mantovani NP, Ferreira MC, Arnold R, Duro RL, Ferreira PR, Hunter JR, Leal É, Diaz RS, Komninakis SV.

  6. Is Hepatitis Delta infections important in Brazil? BMC Infect Dis., v. 16, p. 525-, 2016. Cicero MF, Pena NM, Santana LC, Arnold R, Azevedo RG, Leal ÉS, Diaz RS, Komninakis SV. 

  7. Detection of lamivudine-resistant variants and mutations related to reduced antigenicity of HBsAg in individuals from the cities of Santos and Sao Paulo, Brazil. Virology Journal. , v.10, p.320 - , 2013. Mantovani, N; Cicero, M; Santana, LC; Silveira, C; do Carmo, EP; Ferreira, PR; Caseiro, MM; Komninakis, SV.

  8. Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in Sao Paulo, Brazil. Journal of Clinical Microbiology, v.50, p.2122 - 2125, 2012. Mantovani, N.P.; Azevedo, R. G; Rabelato, J. T.; Sanabani, S. S.; Diaz, R. S.; Komninakis, S. V. 

  9. Evaluation of GB Virus C/Hepatitis G Viral Load Among HIV Type 1-Coinfected Patients in São Paulo, Brazil. AIDS Research and Human Retroviruses. , v.28, p.1301 - 1304, 2012. Alves-Souza, V. K.; Komninakis, S. V.; Baggio-Zappia, G.L.; Barbosa, A. J.; Mantovani, N.P.; Diaz, R. S. ; Ferreira, P. R. A.; Lanzara, G.A.; Granato, C. F. H.

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