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Michael J. Corley, PhD


Research Interest



Fun Fact



B.S. Neuroscience and Behavior - University of California-San Diego, San Diego, CA - 2008

M.A. Behavior Neuroscience - University of Hawai'i at Manoa, Honolulu, HI - 2011 (Advisor: Dr. Lorey K. Takahashi)

Ph.D. Behavior Neuroscience - University of Hawai'i at Manoa, Honolulu, HI - 2013 (Advisor: Dr. Robert J. Blanchard)

Postdoctoral Fellow Epigenetics and Immunology - University of Hawai'i at Manoa, John A. Burns School of Medicine, Honolulu, HI - 2017 (Advisor: Dr. Alika K. Maunakea)


Mu C, Corley MJ, Lee RWY, Wong M, Pang A, Arakaki G, Miyamoto R, Rho JM, Mickiewicz B, Dowlatabadi R, Vogel HJ, Korchemagin Y, Shearer J. Metabolic Framework for the Improvement of Autism Spectrum Disorders by a Modified Ketogenic Diet: A Pilot Study. J Proteome Res. 2020 Jan 3;19(1):382-390. doi: 10.1021/acs.jproteome.9b00581. Epub 2019 Nov 22. PMID: 31696714.

Fujimoto BA, Young M, Carter L, Pang APS, Corley MJ, Fogelgren B, Polgar N. The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells. Am J Physiol Endocrinol Metab. 2019 Dec 1;317(6):E957-E972. doi: 10.1152/ajpendo.00109.2019. Epub 2019 Oct 8. PMID: 31593505.

D'Antoni ML, Kallianpur KJ, Premeaux TA, Corley MJ, Fujita T, Laws EI, Ogata-Arakaki D, Chow DC, Khadka VS, Shikuma CM, Ndhlovu LC. Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection. Front Immunol. 2019;10:2789. doi: 10.3389/fimmu.2019.02789. eCollection 2019. PMID: 31849969.

Corley MJ, Vargas-Maya N, Pang APS, Lum-Jones A, Li D, Khadka V, Sultana R, Blanchard DC, Maunakea AK. Epigenetic Delay in the Neurodevelopmental Trajectory of DNA Methylation States in Autism Spectrum Disorders. Front Genet. 2019;10:907. doi: 10.3389/fgene.2019.00907. eCollection 2019. PMID: 31681403.

Dye CK, Corley MJ, Li D, Khadka VS, Mitchell BI, Sultana R, Lum-Jones A, Shikuma CM, Ndhlovu LC, Maunakea AK. Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults. Clin Epigenetics. 2019 Jun 28;11(1):95. doi: 10.1186/s13148-019-0694-1. PMID: 31253200.

Balaan C, Corley MJ, Eulalio T, Leite-Ahyo K, Pang APS, Fang R, Khadka VS, Maunakea AK, Ward MA. Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder. Behav Brain Res. 2019 Jan 1;356:137-147. doi: 10.1016/j.bbr.2018.08.005. Epub 2018 Aug 19. PMID: 30134148.

Zhang X, Hu Y, Aouizerat BE, Peng G, Marconi VC, Corley MJ, Hulgan T, Bryant KJ, Zhao H, Krystal JH, Justice AC, Xu K. Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality. Clin Epigenetics. 2018 Dec 13;10(1):155. doi: 10.1186/s13148-018-0591-z. PMID: 30545403.

Uzzan M, Tokuyama M, Rosenstein AK, Tomescu C, SahBandar IN, Ko HM, Leyre L, Chokola A, Kaplan-Lewis E, Rodriguez G, Seki A, Corley MJ, Aberg J, La Porte A, Park EY, Ueno H, Oikonomou I, Doron I, Iliev ID, Chen BK, Lui J, Schacker TW, Furtado GC, Lira SA, Colombel JF, Horowitz A, Lim JK, Chomont N, Rahman AH, Montaner LJ, Ndhlovu LC, Mehandru S. Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals. Sci Transl Med. 2018 Oct 3;10(461). doi: 10.1126/scitranslmed.aau4711. PMID: 30282696.

Lee RWY, Corley MJ, Pang A, Arakaki G, Abbott L, Nishimoto M, Miyamoto R, Lee E, Yamamoto S, Maunakea AK, Lum-Jones A, Wong M. A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder. Physiol Behav. 2018 May 1;188:205-211. doi: 10.1016/j.physbeh.2018.02.006. Epub 2018 Feb 5. PMID: 29421589.

Ginwala R, Caruso B, Khan ZK, Pattekar A, Chew GM, Corley MJ, Loonawat R, Jacobson S, Sreedhar S, Ndhlovu LC, Jain P. HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice. J Neuroimmune Pharmacol. 2017 Sep;12(3):504-520. doi: 10.1007/s11481-017-9740-y. Epub 2017 Apr 4. PMID: 28374110.

Corley MJ, Dye C, D'Antoni ML, Byron MM, Yo KL, Lum-Jones A, Nakamoto B, Valcour V, SahBandar I, Shikuma CM, Ndhlovu LC, Maunakea AK. Comparative DNA Methylation Profiling Reveals an Immunoepigenetic Signature of HIV-related Cognitive Impairment. Sci Rep. 2016 Sep 15;6:33310. doi: 10.1038/srep33310. PMID: 27629381.

Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S. A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure. Dis Model Mech. 2016 May 1;9(5):585-96. doi: 10.1242/dmm.024109. Epub 2016 Mar 17. PMID: 26989192.

Corley MJ, Zhang W, Zheng X, Lum-Jones A, Maunakea AK. Semiconductor-based sequencing of genome-wide DNA methylation states. Epigenetics. 2015;10(2):153-66. doi: 10.1080/15592294.2014.1003747. PMID: 25602802.

Meyza KZ, Defensor EB, Jensen AL, Corley MJ, Pearson BL, Pobbe RL, Bolivar VJ, Blanchard DC, Blanchard RJ. The BTBR T+ tf/J mouse model for autism spectrum disorders-in search of biomarkers. Behav Brain Res. 2013 Aug 15;251:25-34. doi: 10.1016/j.bbr.2012.07.021. Epub 2012 Aug 9. Rev PMID: 22958973.

Pearson BL, Corley MJ, Vasconcellos A, Blanchard DC, Blanchard RJ. Heparan sulfate deficiency in autistic postmortem brain tissue from the subventricular zone of the lateral ventricles. Behav Brain Res. 2013 Apr 15;243:138-45. doi: 10.1016/j.bbr.2012.12.062. Epub 2013 Jan 11. PMID: 23318464.

Corley MJ, Meyza KZ, Blanchard DC, Blanchard RJ. Reduced sulfate plasma concentrations in the BTBR T+tf/J mouse model of autism. Physiol Behav. 2012 Dec 5;107(5):663-5. doi: 10.1016/j.physbeh.2012.04.010. Epub 2012 Apr 17. PMID: 22538115.

Defensor EB, Corley MJ, Blanchard RJ, Blanchard DC. Facial expressions of mice in aggressive and fearful contexts. Physiol Behav. 2012 Dec 5;107(5):680-5. doi: 10.1016/j.physbeh.2012.03.024. Epub 2012 Mar 29. PMID: 22484562.

Corley MJ, Caruso MJ, Takahashi LK. Stress-induced enhancement of fear conditioning and sensitization facilitates extinction-resistant and habituation-resistant fear behaviors in a novel animal model of posttraumatic stress disorder. Physiol Behav. 2012 Jan 18;105(2):408-16. doi: 10.1016/j.physbeh.2011.08.037. Epub 2011 Sep 8. PMID: 21925525.

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