Scott A. Bowler, MS

Scott graduated from Oakland University with a BS in Biology in 2015. During this time, Scott worked in the Tiegs’ Aquatic Ecology laboratory researching the environmental impact of engineered shorelines on the Great Lakes. Following graduation, Scott relocated to Honolulu Hawaii and supervised the Blood Processing Lab for the Hawaii Center for AIDS. His work within HIV encouraged Scott to continue his educational career and graduated from the University of Hawaii in December 2020 with a MS in Biomedical Sciences with a focus on Tropical Medicine while under the mentorship of Dr. Ndhlovu. Following graduation, Scott pursued training in Bioinformatics with the University of Hawaii Bioinformatics Core where his research focused on neoantigen identification within a pan cancer cohort.

Research Interest: Computational biology, genomics & genetics, autoimmunity, machine learning

Awards/Accolades:

Pacific Island Partnership for Cancer Health Equity Graduate Research Fellow 2021

Fun Fact: Scott knows five languages: C++, Java, Perl, Python, and English. But is possibly weakest in English.

Hometown: Detroit, Mi

B.S. Biological Sciences - Oakland University, Rochester, Michigan

M.S. Biomedical Science: Tropical Medicine - University of Hawaii at Manoa, Honolulu, Hawaii

Publications

Thomas Alan Premeaux, Stephen Tung Yeung, Zaheer Bukhari, Scott Bowler, Oral Alpan, Raavi Gupta, Lishomwa Ndhlovu. Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed Therapies. Front. immunol. 2022. Doi: 10.3389/fimmu.2022.842740. Epub 2022 Feb 21.

Erika Marques de Menezes, Xutao Deng, Jocelyn Liu, Scott Bowler, Cecilia Shikuma, Mars Stone, Peter Hunt, Lishomwa Ndhlovu, Philip Norris. Plasma CD16+ extracellular vesicles associate with carotid artery intima-media thickness in HIV+ adults on cART. MBio. 2022. Doi: 10.1128/mbio.03005-21.

Kyle W. Kroll, Spandan V. Shah, Olivier A. Lucar, Thomas A. Premeaux, Cecilia M. Shikuma, Michael J. Corley, Matthew Mosher, Scott Bowler, Lishomwa C. Ndhlovu, R. Keith Reeves. Disruption of natural killer cell homing as a biomarker in persons aging with or without HIV. Cell Reports Medicine. 2022. Doi: 10.1016/j.xcm.2022.100773

Scott Bowler, Georgios Papoutsoglou, Aristides Karanikas, Ioannis Tsmardinos, Michael J. Corley, Lishomwa C. Ndhlovu. A Machine Learning Approach Utilizing DNA Methylation as an Accurate Classifier of COVID-19 Disease Severity. Sci. Rep. 2022. Doi: doi.org/10.1038/s41598-022-22201-4

Erika G. Marques de Menezes, Jocelyn Liu, Scott Bowler, Leila B. Giron, Michelle L. D’Antoni, Cecilia M. Shikuma, Mohamed Abdel-Mohsen, Lishomwa C. Ndhlovu, Philip J. Norris. Circulating Brain-derived Extracellular Vesicles are Associated with Monocyte Activation in Individuals with HIV-related Neurocognitive Impairment. Front. Immunol. 2022.Doi: doi.org/10.3389/fimmu.2022.1033712

Carrie D. Johnston, Erika G. Marques de Menezes, Scott Bowler, Eugenia L. Siegler, Courtney Friday, Philip J. Norris, Michelle C. Rice, Mary E. Choi, Marshall J. Glesby, Lishomwa C. Ndhlovu. Plasma Extracellular Vesicles and Cell-Free Mitochondrial DNA are Associated with Cognitive Dysfunction in Treated Older Adults with HIV. **UNDER REVIEW** JNV. 2023.

Bowler S, Chew GM, Budoff M, Chow D, Mitchell BI, DʼAntoni ML, Siriwardhana C, Ndhlovu LC, Shikuma C. PD-1+ and TIGIT+ CD4 T Cells Are Associated With Coronary Artery Calcium Progression in HIV-Infected Treated Adults. J Acquir Immune Defic Syndr. 2019 May 1;81(1):e21-e23. doi: 10.1097/QAI.0000000000002001. PMID: 30865177; PMCID: PMC6458053.

Bowler S, Siriwardhana C, Mitchell BI, D'Antoni ML, Ogata-Arakaki D, Souza S, Yee R, Gangcuangco LMA, Chow DC, Ndhlovu LC, Shikuma C. Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy. HIV Res Clin Pract. 2019 Aug-Oct;20(4-5):123-129. doi: 10.1080/25787489.2020.1719319. Epub 2020 Feb 4. PMID: 32013805.

Gangcuangco LMA, Mitchell BI, Siriwardhana C, Kohorn LB, Chew GM, Bowler S, Kallianpur KJ, Chow DC, Ndhlovu LC, Gerschenson M, Shikuma CM. Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation. PLoS One. 2020 Apr 30;15(4):e0231761. doi: 10.1371/journal.pone.0231761. Erratum in: PLoS One. 2021 Mar 25;16(3):e0249428. PMID: 32353005; PMCID: PMC7192478.

Chow DC, Mau M, Hodis HN, Kewcharoen J, Li Y, Siriwardhana C, Souza SA, Mitchell BI, Bowler S, SahBandar I, Gangcuangco LMA, MacPherson I, Ndhlovu LC, Shikuma CM. Short Communication: Carotid Artery Plaque Burden in HIV Is Associated with Soluble Mediators and Monocytes. AIDS Res Hum Retroviruses. 2020 Dec;36(12):1020-1023. doi: 10.1089/AID.2020.0075. Epub 2020 Sep 28. PMID: 32862657; PMCID: PMC7703087.

Zuo Y, Chen S, Yan L, Hu L, Bowler S, Zitello E, Huang G, Deng Y. Development of a tRNA-derived Small RNA Diagnostic and Prognostic Signature in Liver Cancer. Genes & Diseases. 2021. Doi: 10.1016/j.gendis.2021.01.006

Bowler S, Mitchell BI, Kallianpur KJ, Chow D, Jiang W, Shikuma CM, Ndhlovu LC. Plasma anti-CD4 IgG is associated with brain abnormalities in people with HIV on antiretroviral therapy. J Neurovirol. 2021 Apr;27(2):334-339. doi: 10.1007/s13365-021-00966-0. Epub 2021 Mar 12. PMID: 33710596.