HIV Neuroinflammation and CNS Reservoirs
Since immunological functions are shaped by the host glycome, it is not surprising that inflammation is associated with aberrant glycosylation. Neuro-inflammation during HIV infection involves complex interactions. Dr Ndhlovu co-leads a study investigating glycomic alterations and neuroinflammatory mechanisms of brain health in HIV in a collaboration with investigators at the Wistar Institute and Mount Sinai.
We are evaluating several strategies in persons with early HIV infection or after long-term antiretroviral therapy to better understand HIV related cognitive deficits. One such approach investigates an immunomodulatory glycoprotein and its ability to reactivate and disable the virus particularly in the central nervous system, an important hiding place for HIV