Stephen T. Yeung, PhD

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Stephen graduated from the University of California Irvine in 2013 with a BA in Public Health Policy: Healthcare Management and Policy and New York University in 2018 with a MS in Pathology and in 2020 with a M.Phil in Pathology and Ph.D. in Basic Medical Sciences: Immunology and Inflammation. During his undergrad, Stephen was in Dr. Frank M. LaFerla Lab studying the role of brain injury on adult neurogenesis. Stephen also worked in the Public Health field investigating preventive measures for headaches and alcohol use and dependence among undergraduate students. Prior to beginning his PhD, Stephen continued his research in Dr. Frank M. LaFerla Lab and Dr. Mathew Blurton-Jones Lab studying the therapeutic potential of human neural stem cells as a treatment for Alzheimer’s disease, the effects of repeated cognitive training on Alzheimer’s pathology, and the role of the adaptive immune system on Alzheimer’s disease pathogenesis. At UCHC, his doctoral studies focused on understanding the role of a subset of intestinal macrophages during Shiga toxin Citrobacter rodentium infection and the ontogeny, maintenance, and function of non-lymphoid tissue resident macrophages. Upon transferring to NYU, his research shifted towards understanding the role of tissue resident macrophage subsets in regulating host defense against microbes. Stephen's Ph.D. work investigated the role of tissue resident macrophages in regulating systemic inflammatory diseases (septic shock and Staph aureus/Listeria infections). Upon graduation, Stephen was recruited to remain as an Associate Research Scientist in the lab, with his research focus on host defense against infections (SARS-CoV-2, mTB, Staph aureus, Listeria, Influenza). Upon joining the Ndhlovu Lab, Stephen's interest remains in understand the in situ dysregulation of immune and non-immune cells during infections.

Research Interest: Neurobiology, Behavioral Neuroscience, Neurobiology of Disease, Patient Outcome, Public Health, Public Policy, Innate Immunology, Macrophages, Innate Immune Receptors, Host-Pathogen Interaction, HIV, Infectious Disease, NeuroHIV, Microscopy, Dynamic Microscopy, Biomedical Engineering, Transgenic systems

Awards/Accolades:

  • Recipient, T32, Immunology and Inflammation Training Grant (Sept 2018 – Aug 2020)

    • Program in Immunology and Inflammation

    • Mentor: Kamal M. Khanna, Ph.D.

  • Recipient, Jan Vilcek/David Goldfrab Fellowship Endowment Funds (Dec 2017-Dec 2018)

    • Department of Microbiology

    • Mentor: Kamal M. Khanna, Ph.D.

  • Recipient, Summer Undergraduate Research Program Fellowship (2012)

    • Department of Neurobiology and Behavior

    • Mentor: Frank M. LaFerla, Ph.D

  • Recipient, Undergraduate Research Opportunity Program Fellowship (2012-2013)

    • Department of Neurobiology and Behavior

    • Mentor: Frank M. LaFerla, Ph.D

  • Recipient, Undergraduate Research Opportunity Program Fellowship (2011-2013)

    • Department of Public Health

    • Mentor: David S. Timberlake, PhD. And Zuzana Bic, MD

  • Mentor, Undergraduate Research Opportunity Program Fellowship (2013-2015)

    • Department of Neurobiology and Behavior 

  • Recipient, Alzheimer’s Association Young Scientist Award (2013)

    • Department of Neurobiology and Behavior

    • Mentor: Frank M. LaFerla, Ph.D.​​


Fun Fact: When Stephen is not in lab, he spends his time advocating for the LGBTQ community, aiding in community development, and spending time wandering aimlessly in Manhattan.

Hometown: Baldwin Park, CA

B.A. Public Health Policy: Healthcare Management and Policy, Minor: Biomedical Engineering - University of California, Irvine - 2013
M.S. Pathology - New York University - 2018
M.Phil Pathology - New York University - 2020
Ph.D. Pathology (Immunology and Inflammation) - New York University - 2020 (Advisor: Kamal M. Khanna)

Publications

Yeung ST*, Ural BB*, Damani-Yokota P, Devlin JC, de Vries M, Vera-Licona P, Samji T, Sawai CM, Jang G, Perez OA, Pham Q, Maher L, Loke P, Dittmann M, Reizis B, Khanna KM. Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties. Sci Immunol. 2020 Mar 27;5(45):eaax8756. doi: 10.1126/sciimmunol.aax8756.PMID: 32220976 *Co-first Author

Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, Lin WY, Yeung ST, Silva HM, Li D, Hine A, Loke P, Hudesman D, Martin JC, Kenigsberg E, Merad M, Khanna KM, Littman DR. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. Cell. 2020 Jan 9;180(1):79-91.e16. doi: 10.1016/j.cell.2019.11.026. Epub 2019 Dec 19. PMID: 31866067

Guillamot M, Ouazia D, Dolgalev I, Yeung ST, Kourtis N, Dai Y, Corrigan K, Zea-Redondo L, Saraf A, Florens L, Washburn MP, Tikhonova AN, Malumbres M, Gong Y, Tsirigos A, Park C, Barbieri C, Khanna KM, Busino L, Aifantis I. The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation. Nat Immunol. 2019 Sep;20(9):1196-1207. doi: 10.1038/s41590-019-0454-6. Epub 2019 Aug 12. PMID: 31406379

Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB. Systemic TLR2 tolerance enhances central nervous system remyelination. J Neuroinflammation. 2019 Jul 27;16(1):158. doi: 10.1186/s12974-019-1540-2. PMID: 31351476

Lin JD, Nishi H, Poles J, Niu X, Mccauley C, Rahman K, Brown EJ, Yeung ST, Vozhilla N, Weinstock A, Ramsey SA, Fisher EA, Loke P. Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression. JCI Insight. 2019 Feb 21;4(4). pii: 124574. doi: 10.1172/jci.insight.124574. eCollection 2019 Feb 21. PMID: 30830865

Lubkin A, Lee WL, Alonzo F 3rd, Wang C, Aligo J, Keller M, Girgis NM, Reyes-Robles T, Chan R, O'Malley A, Buckley P, Vozhilla N, Vasquez MT, Su J, Sugiyama M, Yeung ST, Coffre M, Bajwa S, Chen E, Martin P, Kim SY, Loomis C, Worthen GS, Shopsin B, Khanna KM, Weinstock D, Lynch AS, Koralov SB, Loke P, Cadwell K, Torres VJ. Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice. Cell Host Microbe. 2019 Mar 13;25(3):463-470.e9. doi: 10.1016/j.chom.2019.01.015. Epub 2019 Feb 21. PMID: 30799265

Grenier JM, Yeung ST, Khanna KM. Combination Immunotherapy: Taking Cancer Vaccines to the Next Level. Front Immunol. 2018 Mar 22;9:610. doi: 10.3389/fimmu.2018.00610. eCollection 2018. Review. PMID: 29623082

Grenier JM, Yeung ST, Qiu Z, Jellison ER, Khanna KM. Combining Adoptive Cell Therapy with Cytomegalovirus-Based Vaccine Is Protective against Solid Skin Tumors. Front Immunol. 2018 Jan 16;8:1993. doi: 10.3389/fimmu.2017.01993. eCollection 2017. PMID: 29387061

Perez OA, Yeung ST, Vera-Licona P, Romagnoli PA, Samji T, Ural BB, Maher L, Tanaka M, Khanna KM.CD169+ macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen. Sci Immunol. 2017 Oct 6;2(16). pii: eaah5520. doi: 10.1126/sciimmunol.aah5520. PMID: 28986418

​Marsh SE, Yeung ST, Torres M, Davis JL, Capela A, Poon WW, Blurton-Jones M. HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease. Stem Cell Reports. 2017 Feb 14;8(2):235-248. doi: 10.1016/j.stemcr.2016.12.019. PMID: 28199828

Yeung ST*, Lo TCT*, Lee S, Skavinski K, Liao S. Reduction of central neuropathic pain with ketamine infusion in a patient with Ehlers-Danlos syndrome: a case report. J Pain Res. 2016 Sep 15;9:683-687. eCollection 2016. PMID: 27695362*Co-first author

Chen W, Abud EM, Yeung ST, Lakatos A, Nassi T, Wang J, Blum D, Buee L, Poon WW, Blurton-Jones M. Increased tauopathy drives microglia-mediated clearance of beta-amyloid. Acta Neuropathol Commun. 2016 Jun 23;4(1):63. doi: 10.1186/s40478-016-0336-1. PMID: 27339073

Marsh SE, Abud EM*, Lakatos A*, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW, Blurton-Jones M. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1316-25. doi: 10.1073/pnas.1525466113. Epub 2016 Feb 16. PMID: 26884167. *Contribute equally

Yeung ST*, Lo TCT*, Lee S, Chang EY. Hematuria following Botox treatment for upper limb spasticity: a case report. J Pain Res. 2015 Sep 14;8:619-22. doi: 10.2147/JPR.S88658. eCollection 2015. PMID: 26396542 *Co-first author

Yeung ST*, Martinez-Coria H*, Ager RR, Rodriguez-Ortiz CJ, Baglietto-Vargas D, LaFerla FM. Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model. Brain Res Bull. 2015 Aug;117:10-5. doi: 10.1016/j.brainresbull.2015.07.001. Epub 2015 Jul 7. Erratum in: Brain Res Bull. 2015 Oct;119(Pt A):104. PMID: 26162480 *Co-first author

Yeung ST*, Myczek K*, Castello N, Baglietto-Vargas D, LaFerla FM. Hippocampal adaptive response following extensive neuronal loss in an inducible transgenic mouse model. PLoS One. 2014 Sep 3;9(9):e106009. doi: 10.1371/journal.pone.0106009. eCollection 2014. PMID: 25184527 *Co-first author

Yeung ST*, Myczek K*, Kang AP, Chabrier MA, Baglietto-Vargas D, LaFerla FM (2013). Impact of hippocampal neuronal ablation on neurogenesis and cognition in the aged brain. Neuroscience. 2014 Feb 14;259:214-22. doi: 10.1016/j.neuroscience.2013.11.054. Epub 2013 Dec 4. PMID: 24316470 *Co-first author