The Laboratory of
HIV Immunopathogenesis
and Emerging Pathogens

Tregs control the development of symptomatic West Nile virus infection in humans and mice.

Lanteri MC, O'Brien KM, Purtha WE, Cameron MJ, Lund JM, Owen RE, Heitman JW, Custer B, Hirschkorn DF, Tobler LH, Kiely N, Prince HE, Ndhlovu LC, Nixon DF, Kamel HT, Kelvin DJ, Busch MP, Rudensky AY, Diamond MS, Norris PJ.J Clin Invest. 2009 Nov;119(11):3266-77. doi: 10.1172/JCI39387. Epub 2009 Oct 12.PMID: 19855131 

 

Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4.

Milush JM, Long BR, Snyder-Cappione JE, Cappione AJ 3rd, York VA, Ndhlovu LC, Lanier LL, Michaëlsson J, Nixon DF.Blood. 2009 Nov 26;114(23):4823-31. doi: 10.1182/blood-2009-04-216374. Epub 2009 Oct 5.PMID: 19805616 

 

Lower numbers of circulating Natural Killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease.

Ndhlovu LC, Snyder-Cappione JE, Carvalho KI, Leal FE, Loo CP, Bruno FR, Jha AR, Devita D, Hasenkrug AM, Barbosa HM, Segurado AC, Nixon DF, Murphy EL, Kallas EG.Clin Exp Immunol. 2009 Dec;158(3):294-9. doi: 10.1111/j.1365-2249.2009.04019.x. Epub 2009 Sep 2.PMID: 19778295 

 

A decreased frequency of regulatory T cells in patients with common variable immunodeficiency.

Melo KM, Carvalho KI, Bruno FR, Ndhlovu LC, Ballan WM, Nixon DF, Kallas EG, Costa-Carvalho BT.PLoS One. 2009 Jul 29;4(7):e6269. doi: 10.1371/journal.pone.0006269.PMID: 19649263

 

Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population.

Torheim EA, Ndhlovu LC, Pettersen FO, Larsen TL, Jha AR, Torgersen KM, Kvale D, Nixon DF, Taskén K, Aandahl EM.Eur J Immunol. 2009 May;39(5):1280-7. doi: 10.1002/eji.200839002.PMID: 19384871

 

High CD8+ T cell activation marks a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression of viral replication.

Barbour JD, Ndhlovu LC, Xuan Tan Q, Ho T, Epling L, Bredt BM, Levy JA, Hecht FM, Sinclair E.PLoS One. 2009;4(2):e4408. doi: 10.1371/journal.pone.0004408. Epub 2009 Feb 9.PMID: 19198651

 

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.

Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, Wong JC, Satkunarajah M, Schweneker M, Chapman JM, Gyenes G, Vali B, Hyrcza MD, Yue FY, Kovacs C, Sassi A, Loutfy M, Halpenny R, Persad D, Spotts G, Hecht FM, Chun TW, McCune JM, Kaul R, Rini JM, Nixon DF, Ostrowski MA.J Exp Med. 2008 Nov 24;205(12):2763-79. doi: 10.1084/jem.20081398. Epub 2008 Nov 10.PMID: 19001139 

 

Supporting orphans and vulnerable children affected by AIDS: using community-generated definitions to explore patterns of children's vulnerability in Zambia.

Schenk K, Ndhlovu L, Tembo S, Nsune A, Nkhata C, Walusiku B, Watts C.AIDS Care. 2008 Sep;20(8):894-903. doi: 10.1080/09540120701767232.PMID: 18777218

 

Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells.

Chen S, Ndhlovu LC, Takahashi T, Takeda K, Ikarashi Y, Kikuchi T, Murata K, Pandolfi PP, Riccardi C, Ono M, Sugamura K, Ishii N.Eur J Immunol. 2008 Aug;38(8):2229-40. doi: 10.1002/eji.200838167.PMID: 18624295

 

Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.

Ndhlovu LC, Chapman JM, Jha AR, Snyder-Cappione JE, Pagán M, Leal FE, Boland BS, Norris PJ, Rosenberg MG, Nixon DF.AIDS. 2008 May 11;22(8):990-2. doi: 10.1097/QAD.0b013e3282ff884e.PMID: 18453860

 

Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection.

Long BR, Ndhlovu LC, Oksenberg JR, Lanier LL, Hecht FM, Nixon DF, Barbour JD.J Virol. 2008 May;82(10):4785-92. doi: 10.1128/JVI.02449-07. Epub 2008 Feb 27.PMID: 18305035 

 

No evidence of sexual transmission of Kaposi's sarcoma herpes virus in a heterosexual South African population.

Malope BI, MacPhail P, Mbisa G, MacPhail C, Stein L, Ratshikhopha EM, Ndhlovu L, Sitas F, Whitby D.AIDS. 2008 Feb 19;22(4):519-26. doi: 10.1097/QAD.0b013e3282f46582.PMID: 18301065

 

T cell responses to human endogenous retroviruses in HIV-1 infection.

Garrison KE, Jones RB, Meiklejohn DA, Anwar N, Ndhlovu LC, Chapman JM, Erickson AL, Agrawal A, Spotts G, Hecht FM, Rakoff-Nahoum S, Lenz J, Ostrowski MA, Nixon DF.PLoS Pathog. 2007 Nov;3(11):e165. doi: 10.1371/journal.ppat.0030165.PMID: 17997601

 

FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection.

Ndhlovu LC, Loo CP, Spotts G, Nixon DF, Hecht FM.J Leukoc Biol. 2008 Feb;83(2):254-62. doi: 10.1189/jlb.0507281. Epub 2007 Nov 2.PMID: 17982112

 

Understanding the impact of a microfinance-based intervention on women's empowerment and the reduction of intimate partner violence in South Africa.

Kim JC, Watts CH, Hargreaves JR, Ndhlovu LX, Phetla G, Morison LA, Busza J, Porter JD, Pronyk P.Am J Public Health. 2007 Oct;97(10):1794-802. doi: 10.2105/AJPH.2006.095521. Epub 2007 Aug 29.PMID: 17761566

 

Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells.

Chen S, Ishii N, Ine S, Ikeda S, Fujimura T, Ndhlovu LC, Soroosh P, Tada K, Harigae H, Kameoka J, Kasai N, Sasaki T, Sugamura K.Int Immunol. 2006 Feb;18(2):269-77. doi: 10.1093/intimm/dxh366. Epub 2005 Dec 16.PMID: 16361311

 

Expanding role of T-cell costimulators in regulatory T-cell function: recent advances in accessory molecules expressed on both regulatory and nonregulatory T cells.

Ndhlovu LC, Takeda I, Sugamura K, Ishii N.Crit Rev Immunol. 2004;24(4):251-66. doi: 10.1615/critrevimmunol.v24.i4.30.PMID: 15588225

 

Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells.

Takeda I, Ine S, Killeen N, Ndhlovu LC, Murata K, Satomi S, Sugamura K, Ishii N.J Immunol. 2004 Mar 15;172(6):3580-9. doi: 10.4049/jimmunol.172.6.3580.PMID: 15004159

 

Changing patterns of knowledge, reported behaviour and sexually transmitted infections in a South African gold mining community.

Williams BG, Taljaard D, Campbell CM, Gouws E, Ndhlovu L, Van Dam J, Caraël M, Auvert B.AIDS. 2003 Sep 26;17(14):2099-107. doi: 10.1097/00002030-200309260-00011.PMID: 14502013

 

OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses.

Ishii N, Ndhlovu LC, Murata K, Sato T, Kamanaka M, Sugamura K.Eur J Immunol. 2003 Sep;33(9):2372-81. doi: 10.1002/eji.200324031.PMID: 12938213

 

Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice.

Sato T, Ishii N, Murata K, Kikuchi K, Nakagawa S, Ndhlovu LC, Sugamura K.Eur J Immunol. 2002 Nov;32(11):3326-35. doi: 10.1002/1521-4141(200211)32:11<3326::AID-IMMU3326>3.0.CO;2-9.PMID: 12555678

 

Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.

Murata K, Nose M, Ndhlovu LC, Sato T, Sugamura K, Ishii N.J Immunol. 2002 Oct 15;169(8):4628-36. doi: 10.4049/jimmunol.169.8.4628.PMID: 12370402

 

Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis.

Ndhlovu LC, Ishii N, Murata K, Sato T, Sugamura K.J Immunol. 2001 Sep 1;167(5):2991-9. doi: 10.4049/jimmunol.167.5.2991.PMID: 11509650 

 

Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand.

Murata K, Ishii N, Takano H, Miura S, Ndhlovu LC, Nose M, Noda T, Sugamura K.J Exp Med. 2000 Jan 17;191(2):365-74. doi: 10.1084/jem.191.2.365.PMID: 10637280

 

Measuring reproductive health care after Cairo: findings from four situation analysis studies in Africa.

Miller RA, Stein K, Miller K, Ndhlovu L, Maggwa N, Sanogo D, Kondo E.Afr J Fertil Sexual Reprod Heal. 1996 Dec;1(2):92-100.PMID: 12321203

 

A comparison of the 1995 and 1989 Kenya Situation Analysis Study findings.

Miller R, Miller K, Ndhlovu L, Solo J, Achola O.Afr J Fertil Sexual Reprod Heal. 1996 Dec;1(2):162-8.PMID: 12321199

 

The Situation Analysis Study of the family planning program in Kenya.

Miller RA, Ndhlovu L, Gachara MM, Fisher AA.Stud Fam Plann. 1991 May-Jun;22(3):131-43.PMID: 1949097

 

Characteristics of new contraceptive acceptors in Zimbabwe.

Dow T, Chombo J, Ndhlovu L, Shumba P, Dhlodhlo B.Stud Fam Plann. 1986 Mar-Apr;17(2):107-13.PMID: 3705131