Publications (2020 - 2021)

Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19.

Corley MJ, Pang APS, Dody K, Mudd PA, Patterson BK, Seethamraju H, Bram Y, Peluso MJ, Torres L, Iyer NS, Premeaux TA, Yeung ST, Chandar V, Borczuk A, Schwartz RE, Henrich TJ, Deeks SG, Sacha JB, Ndhlovu LC.J Leukoc Biol. 2021 Jan 19. doi: 10.1002/JLB.5HI0720-466R. PMID: 33464637

Hiding in plain sight - platelets, the silent carriers of HIV-1.

Baumer Y, Weatherby TM, Mitchell BI, SahBandar IN, Premeaux TA, Michelle L D, Gutierrez-Huerta CA, Powell-Wiley TM, Brown TR, Boisvert WA, Shikuma CM, Ndhlovu LC.Platelets. 2020 Nov 23:1-5. doi: 10.1080/09537104.2020.1849606. PMID: 33222575

CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14. 

Patterson BK, Seethamraju H, Dhody K, Corley MJ, Kazempour K, Lalezari J, Pang APS, Sugai C, Mahyari E, Francisco EB, Pise A, Rodrigues H, Wu HL, Webb GM, Park BS, Kelly S, Pourhassan N, Lelic A, Kdouh L, Herrera M, Hall E, Bimber BN, Plassmeyer M, Gupta R, Alpan O, O'Halloran JA, Mudd PA, Akalin E, Ndhlovu LC, Sacha JB.Int J Infect Dis. 2020 Nov 10;103:25-32. doi: 10.1016/j.ijid.2020.10.101. PMID: 33186704

Prognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19.

Kim J, Volodarskiy A, Sultana R, Pollie MP, Yum B, Nambiar L, Tafreshi R, Mitlak HW, RoyChoudhury A, Horn EM, Hriljac I, Narula N, Kim S, Ndhlovu L, Goyal P, Safford MM, Shaw L, Devereux RB, Weinsaft JW.J Am Coll Cardiol. 2020 Oct 27;76(17):1965-1977. doi: 10.1016/j.jacc.2020.08.066.PMID: 33092732

Increased Monocyte Inflammatory Responses to Oxidized LDL Are Associated with Insulin Resistance in HIV-Infected Individuals on Suppressive Antiretroviral Therapy.

Mitchell BI, Laws EI, Chow DC, SahBandar IN, Gangcuangco LMA, Shikuma CM, Ndhlovu LC.Viruses. 2020 Oct 5;12(10):1129. doi: 10.3390/v12101129.PMID: 33028018 

 

Effects of Brief Adjunctive Metformin Therapy in Virologically Suppressed HIV-Infected Adults on Polyfunctional HIV-Specific CD8 T cell Responses to PD-L1 Blockade.

Chew G, Padua AJ, Chow D, Souza SA, Clements D, Corley M, Pang A, Alejandria M, Gerschenson M, Shikuma C, Ndhlovu L.AIDS Res Hum Retroviruses. 2020 Oct 6. doi: 10.1089/AID.2020.0172. Online ahead of print.PMID: 33019813

 

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease.

Suárez-Fariñas M, Tokuyama M, Wei G, Huang R, Livanos A, Jha D, Levescot A, Irizar H, Kosoy R, Cording S, Wang W, Losic B, Ungaro R, Di'Narzo A, Martinez-Delgado G, Suprun M, Corley MJ, Stojmirovic A, Houten SM, Peters L, Curran M, Brodmerkel C, Perrigoue J, Friedman JR, Hao K, Schadt EE, Zhu J, Ko HM, Cho J, Dubinsky MC, Sands BE, Ndhlovu L, Cerf-Bensusan N, Kasarskis A, Colombel JF, Harpaz N, Argmann C, Mehandru S.Gastroenterology. 2020 Sep 24:S0016-5085(20)35210-0. doi: 10.1053/j.gastro.2020.09.029. Online ahead of print.PMID: 32980345

 

Impact of Cannabis Use on Brain Structure and Function in Suppressed HIV Infection.

Kallianpur KJ, Birn R, Ndhlovu LC, Souza SA, Mitchell B, Paul R, Chow DC, Kohorn L, Shikuma CM.J Behav Brain Sci. 2020 Aug;10(8):344-370. Epub 2020 Aug 21.PMID: 32968547

 

GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity.

Sakurai T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Kawabe T, Ndhlovu LC, Riccardi C, Kudo H, Wada M, Nio M, So T, Ishii N.FASEB J. 2020 Nov;34(11):14820-14831. doi: 10.1096/fj.202001675R. Epub 2020 Sep 10.PMID: 32910505

 

Carotid Artery Plaque Burden in HIV Is Associated with Soluble Mediators and Monocytes.

Chow DC, Mau M, Hodis HN, Kewcharoen J, Li Y, Siriwardhana C, Souza SA, Mitchell BI, Bowler S, SahBandar I, Gangcuangco LMA, MacPherson I, Ndhlovu LC, Shikuma CM.AIDS Res Hum Retroviruses. 2020 Sep 28. doi: 10.1089/AID.2020.0075. Online ahead of print.PMID: 32862657

 

Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy.

Premeaux TA, Javandel S, Hosaka KRJ, Greene M, Therrien N, Allen IE, Corley MJ, Valcour VG, Ndhlovu LC.Front Immunol. 2020 Jun 30;11:1321. doi: 10.3389/fimmu.2020.01321. eCollection 2020.PMID: 32695109

Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade.

SahBandar IN, Chew GM, Corley MJ, Pang APS, Tsai N, Hanks N, Khadka VS, Klatt NR, Hensley-McBain T, Somsouk M, Vujkovic-Cvijin I, Chow DC, Shikuma CM, Ndhlovu LC.AIDS. 2020 Aug 1;34(10):1451-1460. doi: 10.1097/QAD.0000000000002557.PMID: 32675558

Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19.

Patterson BK, Seethamraju H, Dhody K, Corley MJ, Kazempour K, Lalezari JP, Pang AP, Sugai C, Francisco EB, Pise A, Rodrigues H, Ryou M, Wu HL, Webb GM, Park BS, Kelly S, Pourhassan N, Lelic A, Kdouh L, Herrera M, Hall E, Aklin E, Ndhlovu L, Sacha JB.medRxiv. 2020 May 5:2020.05.02.20084673. doi: 10.1101/2020.05.02.20084673. Preprint.PMID: 32511656

Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation.

Gangcuangco LMA, Mitchell BI, Siriwardhana C, Kohorn LB, Chew GM, Bowler S, Kallianpur KJ, Chow DC, Ndhlovu LC, Gerschenson M, Shikuma CM.PLoS One. 2020 Apr 30;15(4):e0231761. doi: 10.1371/journal.pone.0231761. eCollection 2020.PMID: 32353005