Publications (2010 - 2019)

Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy.

Bowler S, Siriwardhana C, Mitchell BI, D'Antoni ML, Ogata-Arakaki D, Souza S, Yee R, Gangcuangco LMA, Chow DC, Ndhlovu LC, Shikuma C.HIV Res Clin Pract. 2019 Aug-Oct;20(4-5):123-129. doi: 10.1080/25787489.2020.1719319. Epub 2020 Feb 4.PMID: 32013805

 

Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection.

D'Antoni ML, Kallianpur KJ, Premeaux TA, Corley MJ, Fujita T, Laws EI, Ogata-Arakaki D, Chow DC, Khadka VS, Shikuma CM, Ndhlovu LC.Front Immunol. 2019 Nov 29;10:2789. doi: 10.3389/fimmu.2019.02789. eCollection 2019.PMID: 31849969 

 

Short Communication: Metformin Reduces CD4 T Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy.

Shikuma CM, Chew GM, Kohorn L, Souza SA, Chow D, SahBandar IN, Park EY, Hanks N, Gangcuangco LMA, Gerschenson M, Ndhlovu LC.AIDS Res Hum Retroviruses. 2020 Apr;36(4):303-305. doi: 10.1089/AID.2019.0078. Epub 2020 Jan 8.PMID: 31731885

Regional brain volumetric changes despite 2 years of treatment initiated during acute HIV infection.

Kallianpur KJ, Jahanshad N, Sailasuta N, Benjapornpong K, Chan P, Pothisri M, Dumrongpisutikul N, Laws E, Ndhlovu LC, Clifford KM, Paul R, Jagodzinski L, Krebs S, Ananworanich J, Spudich S, Valcour V; SEARCH010/RV254 Study Group.AIDS. 2020 Mar 1;34(3):415-426. doi: 10.1097/QAD.0000000000002436.PMID: 31725432

 

Plasma inflammatory biomarkers link to diffusion tensor imaging metrics in virally suppressed HIV-infected individuals.

Chang K, Premeaux TA, Cobigo Y, Milanini B, Hellmuth J, Rubin LH, Javandel S, Allen I, Ndhlovu LC, Paul R, Valcour V.AIDS. 2020 Feb 1;34(2):203-213. doi: 10.1097/QAD.0000000000002404.PMID: 31634200

 

Frailty Is Associated With Insulin Resistance in Chronic Human Immunodeficiency Virus Infection.

Chow DC, Bernas MA, Gangcuangco LM, Huynh J, Kohorn LB, Kallianpur KJ, Souza SA, Shiramizu B, Ndhlovu LC, Shikuma CM.Clin Infect Dis. 2020 Aug 14;71(4):1127-1128. doi: 10.1093/cid/ciz1017.PMID: 31612202

 

Relationship between Circulating Inflammatory Monocytes and Cardiovascular Disease Measures of Carotid Intimal Thickness.

SahBandar IN, Ndhlovu LC, Saiki K, Kohorn LB, Peterson MM, D'Antoni ML, Shiramizu B, Shikuma CM, Chow DC.J Atheroscler Thromb. 2020 May 1;27(5):441-448. doi: 10.5551/jat.49791. Epub 2019 Oct 4.PMID: 31588100 

 

Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research.

Montano M, Bhasin S, D'Aquila RT, Erlandson KM, Evans WJ, Funderburg NT, Justice A, Ndhlovu LC, Ojikutu B, Pahor M, Pahwa S, Ryan AS, Schrack J, Schultz MB, Sebastiani P, Sinclair DA, Tripp J, Walker B, Womack JA, Yung R, Reeves RK.AIDS Res Hum Retroviruses. 2019 Nov/Dec;35(11-12):999-1012. doi: 10.1089/AID.2019.0130. Epub 2019 Sep 23.PMID: 31456412 

 

Multi-antigen Vaccination With Simultaneous Engagement of the OX40 Receptor Delays Malignant Mesothelioma Growth and Increases Survival in Animal Models.

Hoffmann PR, Hoffmann FW, Premeaux TA, Fujita T, Soprana E, Panigada M, Chew GM, Richard G, Hindocha P, Menor M, Khadka VS, Deng Y, Moise L, Ndhlovu LC, Siccardi A, Weinberg AD, De Groot AS, Bertino P.Front Oncol. 2019 Aug 2;9:720. doi: 10.3389/fonc.2019.00720. eCollection 2019.PMID: 31428586

 

Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion.

Bertino P, Premeaux TA, Fujita T, Haun BK, Marciel MP, Hoffmann FW, Garcia A, Yiang H, Pastorino S, Carbone M, Niki T, Berestecky J, Hoffmann PR, Ndhlovu LC.Oncoimmunology. 2019 Apr 17;8(8):1601482. doi: 10.1080/2162402X.2019.1601482. eCollection 2019.PMID: 31413910

 

S100B and its association with HIV-associated neurocognitive disorders.

Limpruttidham N, Mitchell BI, Kallianpur KJ, Nakamoto BK, Souza SA, Shiramizu B, Ndhlovu LC, Chow DC, Shikuma CM.J Neurovirol. 2019 Dec;25(6):899-900. doi: 10.1007/s13365-019-00773-8. Epub 2019 Jul 5.PMID: 31278533

 

Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults.

Dye CK, Corley MJ, Li D, Khadka VS, Mitchell BI, Sultana R, Lum-Jones A, Shikuma CM, Ndhlovu LC, Maunakea AK.Clin Epigenetics. 2019 Jun 28;11(1):95. doi: 10.1186/s13148-019-0694-1.PMID: 31253200

 

Geriatric Syndromes in Older Adults Living with HIV and Cognitive Impairment.

Hosaka KRJ, Greene M, Premeaux TA, Javandel S, Allen IE, Ndhlovu LC, Valcour V.J Am Geriatr Soc. 2019 Sep;67(9):1913-1916. doi: 10.1111/jgs.16034. Epub 2019 Jun 26.PMID: 31241764

 

Impact of HIV-1 infection on the IGF-1 axis and angiogenic factors in pregnant Cameroonian women receiving antiretroviral therapy.

Esemu LF, Yuosembom EK, Fang R, Rasay S, Fodjo BAY, Nguasong JT, Kidima W, Ekali GL, Chen JJ, Ndhlovu L, Bigoga JD, Taylor DW, Leke RGF, Babakhanyan A.PLoS One. 2019 May 1;14(5):e0215825. doi: 10.1371/journal.pone.0215825. eCollection 2019.PMID: 31042729

 

PD-1+ and TIGIT+ CD4 T Cells Are Associated With Coronary Artery Calcium Progression in HIV-Infected Treated Adults.

Bowler S, Chew GM, Budoff M, Chow D, Mitchell BI, DʼAntoni ML, Siriwardhana C, Ndhlovu LC, Shikuma C.J Acquir Immune Defic Syndr. 2019 May 1;81(1):e21-e23. doi: 10.1097/QAI.0000000000002001.PMID: 30865177 

 

Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling.

Colomb F, Giron LB, Premeaux TA, Mitchell BI, Niki T, Papasavvas E, Montaner LJ, Ndhlovu LC, Abdel-Mohsen M.Front Immunol. 2019 Feb 20;10:267. doi: 10.3389/fimmu.2019.00267. eCollection 2019.PMID: 30842775

 

Impact of Myeloid Reservoirs in HIV Cure Trials.

Mitchell BI, Laws EI, Ndhlovu LC.Curr HIV/AIDS Rep. 2019 Apr;16(2):129-140. doi: 10.1007/s11904-019-00438-5.PMID: 30835045

 

Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals.

Premeaux TA, D'Antoni ML, Abdel-Mohsen M, Pillai SK, Kallianpur KJ, Nakamoto BK, Agsalda-Garcia M, Shiramizu B, Shikuma CM, Gisslén M, Price RW, Valcour V, Ndhlovu LC.J Neurovirol. 2019 Apr;25(2):150-161. doi: 10.1007/s13365-018-0696-3. Epub 2018 Nov 26.PMID: 3047879

 

Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults.

Zhang Z, Chew GM, Shikuma CM, Gangcuangco LMA, Souza SA, Shiramizu B, Nakamoto BK, Gong T, Mannem SR, Mitchell BI, Kallianpur KJ, Ndhlovu LC, Chow DC.HIV Clin Trials. 2018 Oct;19(5):172-176. doi: 10.1080/15284336.2018.1514821. Epub 2018 Nov 13.PMID: 30422099

 

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals.

Uzzan M, Tokuyama M, Rosenstein AK, Tomescu C, SahBandar IN, Ko HM, Leyre L, Chokola A, Kaplan-Lewis E, Rodriguez G, Seki A, Corley MJ, Aberg J, La Porte A, Park EY, Ueno H, Oikonomou I, Doron I, Iliev ID, Chen BK, Lui J, Schacker TW, Furtado GC, Lira SA, Colombel JF, Horowitz A, Lim JK, Chomont N, Rahman AH, Montaner LJ, Ndhlovu LC, Mehandru S.Sci Transl Med. 2018 Oct 3;10(461):eaau4711. doi: 10.1126/scitranslmed.aau4711.PMID: 30282696

 

Cenicriviroc inhibits trans-endothelial passage of monocytes and is associated with impaired E-selectin expression.

D'Antoni ML, Mitchell BI, McCurdy S, Byron MM, Ogata-Arakaki D, Chow D, Mehta NN, Boisvert WA, Lefebvre E, Shikuma CM, Ndhlovu LC, Baumer Y.J Leukoc Biol. 2018 Dec;104(6):1241-1252. doi: 10.1002/JLB.5A0817-328RRR. Epub 2018 Aug 8.PMID: 30088682

 

Resting-state connectivity and spontaneous activity of ventromedial prefrontal cortex predict depressive symptomology and peripheral inflammation in HIV.

McIntosh RC, Paul R, Ndhlovu LC, Hidalgo M, Lobo JD, Walker M, Shikuma CM, Kallianpur KJ.J Neurovirol. 2018 Oct;24(5):616-628. doi: 10.1007/s13365-018-0658-9. Epub 2018 Jul 18.PMID: 30022427 

 

In vivo and in vitro immunogenicity of novel MHC class I presented epitopes to confer protective immunity against chronic HTLV-1 infection.

Mulherkar R, Karabudak A, Ginwala R, Huang X, Rowan A, Philip R, Murphy EL, Clements D, Ndhlovu LC, Khan ZK, Jain P.Vaccine. 2018 Aug 9;36(33):5046-5057. doi: 10.1016/j.vaccine.2018.07.002. Epub 2018 Jul 10.PMID: 30005946 

 

Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities.

D'Antoni ML, Byron MM, Chan P, Sailasuta N, Sacdalan C, Sithinamsuwan P, Tipsuk S, Pinyakorn S, Kroon E, Slike BM, Krebs SJ, Khadka VS, Chalermchai T, Kallianpur KJ, Robb M, Spudich S, Valcour V, Ananworanich J, Ndhlovu LC; RV254/SEARCH010, SEARCH011, and RV304/SEARCH013 Study Groups.J Infect Dis. 2018 Sep 22;218(9):1453-1463. doi: 10.1093/infdis/jiy337.PMID: 29868826 

 

Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism.

DʼAntoni ML, Paul RH, Mitchell BI, Kohorn L, Fischer L, Lefebvre E, Seyedkazemi S, Nakamoto BK, Walker M, Kallianpur KJ, Ogata-Arakaki D, Ndhlovu LC, Shikuma C.J Acquir Immune Defic Syndr. 2018 Sep 1;79(1):108-116. doi: 10.1097/QAI.0000000000001752.PMID: 29781885

Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques.

Hsu DC, Sunyakumthorn P, Wegner M, Schuetz A, Silsorn D, Estes JD, Deleage C, Tomusange K, Lakhashe SK, Ruprecht RM, Lombardini E, Im-Erbsin R, Kuncharin Y, Phuang-Ngern Y, Inthawong D, Chuenarom W, Burke R, Robb ML, Ndhlovu LC, Ananworanich J, Valcour V, O'Connell RJ, Spudich S, Michael NL, Vasan S.J Virol. 2018 May 14;92(11):e00222-18. doi: 10.1128/JVI.00222-18. Print 2018 Jun 1.PMID: 29563297

GITR cosignal in ILC2s controls allergic lung inflammation.

Nagashima H, Okuyama Y, Fujita T, Takeda T, Motomura Y, Moro K, Hidaka T, Omori K, Sakurai T, Machiyama T, Ndhlovu LC, Riccardi C, So T, Ishii N.J Allergy Clin Immunol. 2018 May;141(5):1939-1943.e8. doi: 10.1016/j.jaci.2018.01.028. Epub 2018 Feb 8.PMID: 29427641

 

CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection.

Hsu DC, Wegner MD, Sunyakumthorn P, Silsorn D, Tayamun S, Inthawong D, Kuncharin Y, Im-Erbsin R, Ege C, O'Connell RJ, Michael NL, Ndhlovu LC, Vasan S.J Med Primatol. 2017 Aug;46(4):154-157. doi: 10.1111/jmp.12298.PMID: 28748665

 

Ultra-Deep Sequencing Analysis on HIV Drug-Resistance-Associated Mutations Among HIV-Infected Individuals: First Report from the Philippines.

SahBandar IN, Samonte G, Telan E, Siripong N, Belcaid M, Schanzenbach D, Leano S, Chagan-Yasutan H, Hattori T, Shikuma CM, Ndhlovu LC.AIDS Res Hum Retroviruses. 2017 Nov;33(11):1099-1106. doi: 10.1089/AID.2016.0151. Epub 2017 Jul 5.PMID: 28569550

 

Role of Natural Killer Cells in HIV-Associated Malignancies.

Leal FE, Premeaux TA, Abdel-Mohsen M, Ndhlovu LC.Front Immunol. 2017 Mar 21;8:315. doi: 10.3389/fimmu.2017.00315. eCollection 2017.PMID: 28377768

 

HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice.

Ginwala R, Caruso B, Khan ZK, Pattekar A, Chew GM, Corley MJ, Loonawat R, Jacobson S, Sreedhar S, Ndhlovu LC, Jain P.J Neuroimmune Pharmacol. 2017 Sep;12(3):504-520. doi: 10.1007/s11481-017-9740-y. Epub 2017 Apr 4.PMID: 28374110

 

Plasminogen Activator Inhibitor-1 Predicts Negative Alterations in Whole-Body Insulin Sensitivity in Chronic HIV Infection.

Wirunsawanya K, Belyea L, Shikuma C, Watanabe RM, Kohorn L, Shiramizu B, Mitchell BI, Souza SA, Keating SM, Norris PJ, Ndhlovu LC, Chow D.AIDS Res Hum Retroviruses. 2017 Jul;33(7):723-727. doi: 10.1089/AID.2016.0292. Epub 2017 Apr 18.PMID: 28322572

 

High 25-hydroxyvitamin D is associated with unexpectedly high plasma inflammatory markers in HIV patients on antiretroviral therapy.

Gangcuangco LM, Kohorn LB, Chow DC, Keating SM, Norris PJ, Nagamine LS, Ndhlovu LC, Souza SA, Kallianpur KJ, Shikuma CM.Medicine (Baltimore). 2016 Oct;95(43):e5270. doi: 10.1097/MD.0000000000005270.PMID: 2778739

 

Frailty Characteristics in Chronic HIV Patients are Markers of White Matter Atrophy Independently of Age and Depressive Symptoms: A Pilot Study.

Kallianpur KJ, Sakoda M, Gangcuangco LM, Ndhlovu LC, Umaki T, Chow D, Wongjittraporn S, Shikuma CM.Open Med J. 2016;3:138-152. doi: 10.2174/1874220301603010138. Epub 2016 Aug 29.PMID: 27721908

 

Comparative DNA Methylation Profiling Reveals an Immunoepigenetic Signature of HIV-related Cognitive Impairment.

Corley MJ, Dye C, D'Antoni ML, Byron MM, Yo KL, Lum-Jones A, Nakamoto B, Valcour V, SahBandar I, Shikuma CM, Ndhlovu LC, Maunakea AK.Sci Rep. 2016 Sep 15;6:33310. doi: 10.1038/srep33310.PMID: 27629381

 

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.

Abdel-Mohsen M, Chavez L, Tandon R, Chew GM, Deng X, Danesh A, Keating S, Lanteri M, Samuels ML, Hoh R, Sacha JB, Norris PJ, Niki T, Shikuma CM, Hirashima M, Deeks SG, Ndhlovu LC, Pillai SK.PLoS Pathog. 2016 Jun 2;12(6):e1005677. doi: 10.1371/journal.ppat.1005677. eCollection 2016 Jun.PMID: 27253379

 

Non-classical monocytes predict progression of carotid artery bifurcation intima-media thickness in HIV-infected individuals on stable antiretroviral therapy.

Chow DC, Kagihara JM, Zhang G, Souza SA, Hodis HN, Li Y, Mitchell BI, Nakamoto BK, Kallianpur KJ, Keating SM, Norris PJ, Kohorn LB, Ndhlovu LC, Shikuma CM.HIV Clin Trials. 2016 May;17(3):114-22. doi: 10.1080/15284336.2016.1162386. Epub 2016 Apr 4.PMID: 27125366

 

Elevation of Non-Classical (CD14+/lowCD16++) Monocytes Is Associated with Increased Albuminuria and Urine TGF-β1 in HIV-Infected Individuals on Stable Antiretroviral Therapy.

Mitchell BI, Byron MM, Ng RC, Chow DC, Ndhlovu LC, Shikuma CM.PLoS One. 2016 Apr 20;11(4):e0153758. doi: 10.1371/journal.pone.0153758. eCollection 2016.PMID: 27097224

 

Strategies to target non-T-cell HIV reservoirs.

Sacha JB, Ndhlovu LC.Curr Opin HIV AIDS. 2016 Jul;11(4):376-82. doi: 10.1097/COH.0000000000000283.PMID: 27023285

 

Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients.

Kallianpur KJ, Gerschenson M, Mitchell BI, LiButti DE, Umaki TM, Ndhlovu LC, Nakamoto BK, Chow DC, Shikuma CM.Mitochondrion. 2016 May;28:8-15. doi: 10.1016/j.mito.2016.02.006. Epub 2016 Feb 23.PMID: 26923169 

 

CD4/CD8 Ratio Predicts Peripheral Fat in HIV-Infected Population.

Riangwiwat T, Kohorn LB, Chow DC, Souza SA, Ndhlovu LC, Wong JW, Gangcuangco LM, Shikuma CM.J Acquir Immune Defic Syndr. 2016 May 1;72(1):e17-9. doi: 10.1097/QAI.0000000000000955.PMID: 26885805

 

Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy.

Zungsontiporn N, Tello RR, Zhang G, Mitchell BI, Budoff M, Kallianpur KJ, Nakamoto BK, Keating SM, Norris PJ, Ndhlovu LC, Souza SA, Shikuma CM, Chow DC.PLoS One. 2016 Feb 11;11(2):e0149143. doi: 10.1371/journal.pone.0149143. eCollection 2016.PMID: 26867220

 

Atazanavir use and carotid intima media thickness progression in HIV: potential influence of bilirubin.

Chow D, Kohorn L, Souza S, Ndhlovu L, Ando A, Kallianpur KJ, Byron MM, Baumer Y, Keating S, Shikuma C.AIDS. 2016 Feb 20;30(4):672-4. doi: 10.1097/QAD.0000000000000970.PMID: 26825035

 

Serum amyloid P (SAP) is associated with impaired brachial artery flow-mediated dilation in chronically HIV-1 infected adults on stable antiretroviral therapy.

Zungsontiporn N, Ndhlovu LC, Mitchell BI, Stein JH, Kallianpur KJ, Nakamoto B, Keating SM, Norris PJ, Souza SA, Shikuma CM, Chow DC.HIV Clin Trials. 2015 Nov;16(6):228-35. doi: 10.1179/1945577115Y.0000000007.PMID: 26777795

 

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.

Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC.PLoS Pathog. 2016 Jan 7;12(1):e1005349. doi: 10.1371/journal.ppat.1005349. eCollection 2016 Jan.PMID: 26741490 

 

The meningeal lymphatic system: a route for HIV brain migration?

Lamers SL, Rose R, Ndhlovu LC, Nolan DJ, Salemi M, Maidji E, Stoddart CA, McGrath MS.J Neurovirol. 2016 Jun;22(3):275-81. doi: 10.1007/s13365-015-0399-y. Epub 2015 Nov 16.PMID: 26572785

 

Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais.

Ndhlovu LC, D'Antoni ML, Ananworanich J, Byron MM, Chalermchai T, Sithinamsuwan P, Tipsuk S, Ho E, Slike BM, Schuetz A, Zhang G, Agsalda-Garcia M, Shiramizu B, Shikuma CM, Valcour V; SEARCH 011 study group.J Neuroimmunol. 2015 Nov 15;288:25-33. doi: 10.1016/j.jneuroim.2015.08.020. Epub 2015 Sep 4.PMID: 26531691

 

Preclinical development of HIvax: Human survivin highly immunogenic vaccines.

Hoffmann PR, Panigada M, Soprana E, Terry F, Bandar IS, Napolitano A, Rose AH, Hoffmann FW, Ndhlovu LC, Belcaid M, Moise L, De Groot AS, Carbone M, Gaudino G, Matsui T, Siccardi A, Bertino P.Hum Vaccin Immunother. 2015;11(7):1585-95. doi: 10.1080/21645515.2015.1050572.PMID: 26042612

 

Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression.

Clayton KL, Douglas-Vail MB, Nur-ur Rahman AK, Medcalf KE, Xie IY, Chew GM, Tandon R, Lanteri MC, Norris PJ, Deeks SG, Ndhlovu LC, Ostrowski MA.J Virol. 2015 Apr;89(7):3723-36. doi: 10.1128/JVI.00006-15. Epub 2015 Jan 21.PMID: 25609823

 

Characterization of lipid composition and high-density lipoprotein function in HIV-infected individuals on stable antiretroviral regimens.

Munger AM, Chow DC, Playford MP, Parikh NI, Gangcuangco LM, Nakamoto BK, Kallianpur KJ, Ndhlovu LC, Shikuma CM, Mehta NN.AIDS Res Hum Retroviruses. 2015 Feb;31(2):221-8. doi: 10.1089/AID.2014.0239. Epub 2014 Dec 29.PMID: 25416403

 

Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques.

Fujita T, Burwitz BJ, Chew GM, Reed JS, Pathak R, Seger E, Clayton KL, Rini JM, Ostrowski MA, Ishii N, Kuroda MJ, Hansen SG, Sacha JB, Ndhlovu LC.J Immunol. 2014 Dec 1;193(11):5576-83. doi: 10.4049/jimmunol.1400961. Epub 2014 Oct 27.PMID: 25348621

 

Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-associated neurocognitive disease (HAND).

Ndhlovu LC, Umaki T, Chew GM, Chow DC, Agsalda M, Kallianpur KJ, Paul R, Zhang G, Ho E, Hanks N, Nakamoto B, Shiramizu BT, Shikuma CM.J Neurovirol. 2014 Dec;20(6):571-82. doi: 10.1007/s13365-014-0279-x. Epub 2014 Sep 17.PMID: 25227930

 

Albuminuria is associated with elevated acute phase reactants and proinflammatory markers in HIV-infected patients receiving suppressive combination antiretroviral therapy.

O-charoen P, Ndhlovu LC, Gangcuangco LM, Keating SM, Norris PJ, Ng RC, Mitchell BI, Shikuma CM, Chow DC.AIDS Res Hum Retroviruses. 2014 Dec;30(12):1185-91. doi: 10.1089/AID.2014.0072.PMID: 25205472

 

Elevated levels of full-length and thrombin-cleaved osteopontin during acute dengue virus infection are associated with coagulation abnormalities.

Chagan-Yasutan H, Lacuesta TL, Ndhlovu LC, Oguma S, Leano PS, Telan EF, Kubo T, Morita K, Uede T, Dimaano EM, Hattori T.Thromb Res. 2014 Aug;134(2):449-54. doi: 10.1016/j.thromres.2014.05.003. Epub 2014 May 14.PMID: 24861695

 

Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers.

Tandon R, Chew GM, Byron MM, Borrow P, Niki T, Hirashima M, Barbour JD, Norris PJ, Lanteri MC, Martin JN, Deeks SG, Ndhlovu LC.AIDS Res Hum Retroviruses. 2014 Jul;30(7):654-64. doi: 10.1089/AID.2014.0004. Epub 2014 May 28.PMID: 24786365

 

Increased frequency of Tim-3 expressing T cells is associated with symptomatic West Nile virus infection.

Lanteri MC, Diamond MS, Law JP, Chew GM, Wu S, Inglis HC, Wong D, Busch MP, Norris PJ, Ndhlovu LC.PLoS One. 2014 Mar 18;9(3):e92134. doi: 10.1371/journal.pone.0092134. eCollection 2014.PMID: 24642562

 

Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV.

Shikuma CM, Chow DC, Gangcuangco LM, Zhang G, Keating SM, Norris PJ, Seto TB, Parikh N, Kallianpur KJ, Nakamoto BK, Nagamine LS, Ndhlovu LC, Barbour JD.PLoS One. 2014 Feb 27;9(2):e90330. doi: 10.1371/journal.pone.0090330. eCollection 2014.PMID: 24587328

 

Concomitant evaluation of PMA+ionomycin-induced kinase phosphorylation and cytokine production in T cell subsets by flow cytometry.

Crawford TQ, Jalbert E, Ndhlovu LC, Barbour JD.Cytometry A. 2014 Mar;85(3):268-76. doi: 10.1002/cyto.a.22444. Epub 2014 Jan 24.PMID: 24464647

 

Reduced CD14 expression on classical monocytes and vascular endothelial adhesion markers independently associate with carotid artery intima media thickness in chronically HIV-1 infected adults on virologically suppressive anti-retroviral therapy.

Barbour JD, Jalbert EC, Chow DC, Gangcuangco LM, Norris PJ, Keating SM, Heitman J, Nagamine L, Seto T, Ndhlovu LC, Nakamoto BK, Hodis HN, Parikh NI, Shikuma CM.Atherosclerosis. 2014 Jan;232(1):52-8. doi: 10.1016/j.atherosclerosis.2013.10.021. Epub 2013 Oct 31.PMID: 24401216

 

T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases.

Clayton KL, Haaland MS, Douglas-Vail MB, Mujib S, Chew GM, Ndhlovu LC, Ostrowski MA.J Immunol. 2014 Jan 15;192(2):782-91. doi: 10.4049/jimmunol.1302663. Epub 2013 Dec 13.PMID: 24337741

 

Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection.

Chagan-Yasutan H, Ndhlovu LC, Lacuesta TL, Kubo T, Leano PS, Niki T, Oguma S, Morita K, Chew GM, Barbour JD, Telan EF, Hirashima M, Hattori T, Dimaano EM.J Clin Virol. 2013 Dec;58(4):635-40. doi: 10.1016/j.jcv.2013.10.022. Epub 2013 Oct 27.PMID: 24239423

 

Activation associated ERK1/2 signaling impairments in CD8+ T cells co-localize with blunted polyclonal and HIV-1 specific effector functions in early untreated HIV-1 infection.

Crawford TQ, Hecht FM, Pilcher CD, Ndhlovu LC, Barbour JD.PLoS One. 2013 Oct 15;8(10):e77412. doi: 10.1371/journal.pone.0077412. eCollection 2013.PMID: 24143233

 

The role of HIV and monocytes/macrophages in adipose tissue biology.

Shikuma CM, Gangcuangco LM, Killebrew DA, Libutti DE, Chow DC, Nakamoto BK, Liang CY, Milne CI, Ndhlovu LC, Barbour JD, Shiramizu BT, Gerschenson M.J Acquir Immune Defic Syndr. 2014 Feb 1;65(2):151-9. doi: 10.1097/01.qai.0000435599.27727.6c.PMID: 24091690

 

LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells.

Jones RB, Song H, Xu Y, Garrison KE, Buzdin AA, Anwar N, Hunter DV, Mujib S, Mihajlovic V, Martin E, Lee E, Kuciak M, Raposo RA, Bozorgzad A, Meiklejohn DA, Ndhlovu LC, Nixon DF, Ostrowski MA.J Virol. 2013 Dec;87(24):13307-20. doi: 10.1128/JVI.02257-13. Epub 2013 Oct 2.PMID: 24089548

 

IL-1Β enriched monocytes mount massive IL-6 responses to common inflammatory triggers among chronically HIV-1 infected adults on stable anti-retroviral therapy at risk for cardiovascular disease.

Jalbert E, Crawford TQ, D'Antoni ML, Keating SM, Norris PJ, Nakamoto BK, Seto T, Parikh NI, Shikuma CM, Ndhlovu LC, Barbour JD.PLoS One. 2013 Sep 25;8(9):e75500. doi: 10.1371/journal.pone.0075500. eCollection 2013.PMID: 24086545

 

Albuminuria as a marker of cardiovascular risk in HIV-infected individuals receiving stable antiretroviral therapy.

Tongma C, Shikuma CM, Nakamoto BK, Kallianpur KJ, Umaki TM, Barbour JD, Ndhlovu L, Parikh NI, Chow DC.Hawaii J Med Public Health. 2013 Sep;72(9 Suppl 4):34-8.PMID: 24052917

 

Plasma monocyte chemoattractant protein-1 and tumor necrosis factor-α levels predict the presence of coronary artery calcium in HIV-infected individuals independent of traditional cardiovascular risk factors.

Shikuma CM, Barbour JD, Ndhlovu LC, Keating SM, Norris PJ, Budoff M, Parikh N, Seto T, Gangcuangco LM, Ogata-Arakaki D, Chow D.AIDS Res Hum Retroviruses. 2014 Feb;30(2):142-6. doi: 10.1089/AID.2013.0183. Epub 2013 Sep 21.PMID: 23984974

 

CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis.

Batista MD, Tincati C, Milush JM, Ho EL, Ndhlovu LC, York VA, Kallas EG, Kalil J, Keating SM, Norris PJ, Chang D, Unemori P, Leslie KS, Maurer T, Liao W, Nixon DF.PLoS One. 2013;8(2):e52144. doi: 10.1371/journal.pone.0052144. Epub 2013 Feb 28.PMID: 23468834

 

Sequential staining improves detection of CCR2 and CX3CR1 on monocytes when simultaneously evaluating CCR5 by multicolor flow cytometry.

Jalbert E, Shikuma CM, Ndhlovu LC, Barbour JD.Cytometry A. 2013 Mar;83(3):280-6. doi: 10.1002/cyto.a.22257. Epub 2013 Jan 22.PMID: 23426986 

 

Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications.

Leal FE, Ndhlovu LC, Hasenkrug AM, Bruno FR, Carvalho KI, Wynn-Williams H, Neto WK, Sanabani SS, Segurado AC, Nixon DF, Kallas EG.PLoS Negl Trop Dis. 2013;7(2):e2028. doi: 10.1371/journal.pntd.0002028. Epub 2013 Feb 7.PMID: 23409198 

 

Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children.

Tandon R, Giret MT, Sengupta D, York VA, Wiznia AA, Rosenberg MG, Kallas EG, Ndhlovu LC, Nixon DF.PLoS One. 2012;7(9):e45733. doi: 10.1371/journal.pone.0045733. Epub 2012 Sep 24.PMID: 23029209 

 

Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity.

Ndhlovu LC, Lopez-Vergès S, Barbour JD, Jones RB, Jha AR, Long BR, Schoeffler EC, Fujita T, Nixon DF, Lanier LL.Blood. 2012 Apr 19;119(16):3734-43. doi: 10.1182/blood-2011-11-392951. Epub 2012 Mar 1.PMID: 22383801

 

HIV-1 infection abrogates CD8+ T cell mitogen-activated protein kinase signaling responses.

Crawford TQ, Ndhlovu LC, Tan A, Carvidi A, Hecht FM, Sinclair E, Barbour JD.J Virol. 2011 Dec;85(23):12343-50. doi: 10.1128/JVI.05682-11. Epub 2011 Sep 21.PMID: 21937661

 

Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects.

Tandon R, SenGupta D, Ndhlovu LC, Vieira RG, Jones RB, York VA, Vieira VA, Sharp ER, Wiznia AA, Ostrowski MA, Rosenberg MG, Nixon DF.J Virol. 2011 Nov;85(21):11526-31. doi: 10.1128/JVI.05418-11. Epub 2011 Aug 31.PMID: 21880743

 

HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.

Ndhlovu LC, Leal FE, Hasenkrug AM, Jha AR, Carvalho KI, Eccles-James IG, Bruno FR, Vieira RG, York VA, Chew GM, Jones RB, Tanaka Y, Neto WK, Sanabani SS, Ostrowski MA, Segurado AC, Nixon DF, Kallas EG.PLoS Negl Trop Dis. 2011 Apr 26;5(4):e1030. doi: 10.1371/journal.pntd.0001030.PMID: 21541358

 

Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection.

SenGupta D, Tandon R, Vieira RG, Ndhlovu LC, Lown-Hecht R, Ormsby CE, Loh L, Jones RB, Garrison KE, Martin JN, York VA, Spotts G, Reyes-Terán G, Ostrowski MA, Hecht FM, Deeks SG, Nixon DF.J Virol. 2011 Jul;85(14):6977-85. doi: 10.1128/JVI.00179-11. Epub 2011 Apr 27.PMID: 21525339

 

A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-α and MIP1-β, a lack of IL-17, and a Th1-bias in males.

Snyder-Cappione JE, Tincati C, Eccles-James IG, Cappione AJ, Ndhlovu LC, Koth LL, Nixon DF.PLoS One. 2010 Nov 3;5(11):e15412. doi: 10.1371/journal.pone.0015412.PMID: 21082024

 

IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the periphery.

Ndhlovu LC, Sinclair E, Epling L, Tan QX, Ho T, Jha AR, Eccles-James I, Tincati C, Levy JA, Nixon DF, Hecht FM, Barbour JD.J Clin Immunol. 2010 Sep;30(5):681-92. doi: 10.1007/s10875-010-9432-3. Epub 2010 Jun 23.PMID: 20571894 

 

A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties.

Ndhlovu LC, Leal FE, Eccles-James IG, Jha AR, Lanteri M, Norris PJ, Barbour JD, Wachter DJ, Andersson J, Taskén K, Torheim EA, Aandahl EM, Kallas EG, Nixon DF.Eur J Immunol. 2010 Jan;40(1):134-41. doi: 10.1002/eji.200939258.PMID: 19877008